Vitamin PP Angelini ® - Nicotinamide 🆙

Mechanism of action Vitamin PP Angelini ® - Nicotinamide

Nicotinamide, also known as vitamin B3 or vitamin PP, is a water-soluble vitamin required for the synthesis of essential coenzymes for normal redox reactions such as nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate ( NADP).
By balancing the cellular economy, the above compounds guarantee:

The implementation of the correct redox reactions, necessary both in the catabolic phase and in the biosynthetic phase of the different macromolecules (fatty acids, proteins and carbohydrates);
The control of numerous cell activation pathways, necessary to regulate fundamental activities such as proliferation, cell differentiation, apoptosis and survival.

The deficiency of vitamin B3, fortunately rare nowadays and present almost exclusively in developing countries or in cancer patients with carcinoid syndrome, manifests itself with a serious pathology called pellagra characterized by severe gastro-intestinal and neurological disorders such as diarrhea, nausea, vomiting, headache, depression, disorientation, memory loss and dementia.

Studies carried out and clinical efficacy

1. NICOTINAMIDE AND PANCREATIC FUNCTIONALITY

J Clin Endocrinol Metab. 1993 Dec;77(6):1574-6.

Effects of nicotinamide supplementation on human pancreatic islet function in tissue culture.

Sandler S, Hellerström C, Eizirk DL.

Experimental study that tries to characterize from a molecular point of view, the beneficial effects on pancreatic beta function exerted by the administration of nicotinamide.

2. DIET LOW NICOTINAMIDE AND CONGENITAL CARDIAC DEFECTS

Eur J Nutr. 2008 Oct;47(7):357-65. Epub 2008 Sep 8.

Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects.

Smedts HP, Rakhshandehroo M, Verkleij-Hagoort AC, de Vries JH, Ottenkamp J, Steegers EA, Steegers-Theunissen RP.

Work that demonstrates how a diet rich in saturated fatty acids and low in B vitamins, such as riboflavin and nicotinamide, can significantly increase the risk of developing heart disease in the unborn child.

3. NICOTINAMIDE AND CIGARETTE SMOKE

Nutr Cancer. 1998;32(2):113-20.

Nicotinic acid supplementation: effects on niacin status, cytogenetic damage, and poly(ADP-ribosylation) in lymphocytes of smokers.

Hageman GJ, Stierum RH, van Herwijnen MH, van der Veer MS, Kleinjans JC.

Study that demonstrates how the intake of nicotinamide can contribute minimally to the reduction of the genotoxic damage exerted by the carcinogenic catabolites of cigarette smoke.

Method of use and dosage

VITAMIN PP ®
Solution for injection for intramuscular use of 100 mg nicotinamide per ml solution:
the administration of vitamin PP should be carried out under close medical supervision.
In general, the use of 1 or 2 daily ampoules, taken intramuscularly, should be sufficient to restore normal concentrations of this vitamin and cause a regression of symptoms.

Warnings Vitamin PP Angelini ® - Nicotinamide

The intake of anti-tuberculosis drugs such as ionazide, could determine an increase in the need for nicotinamide, thus requiring the need for supplementation.
The 18 mg per day of nicotinamide could be achieved, without too much difficulty, through a balanced diet containing foods of animal origin.
Parenteral administration was more frequently associated with the occurrence of adverse reactions of an allergic nature, mainly concentrated at the injection site.

PREGNANCY AND BREASTFEEDING

Nicotinamide has been shown to be devoid of fetal toxicity, when taken during the period of pregnancy, according to appropriate medical indications.
Experimental studies also show how this vitamin can antagonize the teratogenic effect of various chemical inducers.

Interactions

Although there are currently no known active ingredients capable of significantly altering the pharmacokinetic properties of nicotinamide, concomitant administration of lovastatin appears to significantly increase the risk of rhabdomyolysis.

Contraindications Vitamin PP Angelini ® - Nicotinamide

The intake of VITAMIN PP ® is contraindicated in case of hypersensitivity to the active ingredient or to one of its excipients.

Undesirable Effects - Side Effects

Disproportionate intake and particularly high doses of nicotinamide have been associated with the appearance of gastrointestinal symptoms such as nausea and vomiting and neurological symptoms such as hot flashes.
In some cases, even at lower doses, it was possible to observe a reddening of the skin of the face, upper limbs and chest, fortunately without clinical relevance.